Publications of Alkaloid biosynthesis Group

Our new 2022 publications!

  • The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis
    18 octobre 2022
    The Vinca minor genome finally assembled! Our new publication in G3!The Vinca minor plant synthesizes monoterpene indole alkaloids (MIAs), which are a class of specialized metabolites displaying a wide range of bioactive- and pharmacologically important properties. V. minor mainly accumulates vincamine, which is commercially used as a nootropic. Using a combination of Oxford Nanopore Technologies long read- and Illumina short-read sequencing, a 679,098 Mb V. minor genome was assembled into 296 scaffolds with an N50 scaffold length of 6 Mb, and encoding 29,624 genes.
  • A microbial supply chain for production of the anti-cancer drug vinblastine published in NATURE!
    31 août 2022
    The authors engineered yeast to produce the cancer therapeutic vinblastine. A promising achievement for the synthetis of therapeutic natural products. This is the latest research of several teams including MIAMi project collaborators. Dr Vincent Courdavault , assistant professor in our lab and Emily A. Stander, former post-doctoral researcher are co-authors of this paper published in Nature.
  • Social amoebae as a new chassis for drug production
    21 février 2022 - 21 février 2024
    Social amoebae as a new chassis for drug production : our new spotlight published in Trends in Biotechnology
  • Chromosome-scale genomes throw light on plant drug biosynthesis
    14 février 2022 - 30 septembre 2024
    Recent chromosome-scale genomes from prominent medicinal plants have provided unprecedent insight into the architecture and evolution of some prominent metabolic pathways. A story related in our new paper published in Trends in Pharmacological Sciences!
  • Marine drugs: Biology, pipelines, current and future prospects for production
    13 décembre 2021 - 30 juin 2024
    Do you know that marine organisms represent a huge reservoir of new pharmaceuticals? If you are interested, read our new research review paper published in Biotechnology advances!

Articles published in 2021

  •  Kulagina N, Besseau S, Godon C, Goldman GH, Papon N,  Courdavault V. .Yeasts as Biopharmaceutical Production Platform. Front. Fungal Biol. 2021 :
  • Koudounas K, Guirimand G, Rojas Hoyos LF, et al. Tonoplast and Peroxisome Targeting of γ-tocopherol N-methyltransferase Homologs Involved in the Synthesis of Monoterpene Indole Alkaloids [published online ahead of print, 2021 Nov 10]. Plant Cell Physiol. 2021;pcab160. doi:10.1093/pcp/pcab160
  • Kulagina N, Perrin J, Besseau S, Courdavault V. Efficient Terpene Production by Marine Thraustochytrids: Shedding Light on the Thermodynamic Driving Force. mBio. 2021;12(5):e0197621. doi:10.1128/mBio.01976-21
  • Yamamoto K, Grzech D, Koudounas K, et al. Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus. Plant Physiol. 2021;187(2):846-857. doi:10.1093/plphys/kiab285
  • Méteignier LV, Papon N, Courdavault V. Plant to Insect Horizontal Gene Transfer: Empowering Whiteflies. Trends Genet. 2021;37(8):688-690. doi:10.1016/j.tig.2021.04.007
  • Kulagina N, Guirimand G, Melin C, et al. Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories [published online ahead of print, 2021 Jul 24]. Microb Biotechnol. 2021;10.1111/1751-7915.13898. doi:10.1111/1751-7915.13898
  • Stander EA, Dugé de Bernonville T, Papon N, Courdavault V. Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin. Comput Struct Biotechnol J. 2021;19:3659-3663. Published 2021 Jun 22. doi:10.1016/j.csbj.2021.06.028
  • Lemos Cruz P, Kulagina N, Guirimand G, et al. Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories. Molecules. 2021;26(12):3596. Published 2021 Jun 11. doi:10.3390/molecules26123596
  • Courdavault V, O'Connor SE, Jensen MK, Papon N. Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits [published online ahead of print, 2021 May 10]. Nat Prod Rep. 2021;10.1039/d0np00092b. doi:10.1039/d0np00092b
  • Kulagina N, Besseau S, Papon N, Courdavault V. Peroxisomes: A New Hub for Metabolic Engineering in Yeast. Front Bioeng Biotechnol. 2021;9:659431. Published 2021 Apr 7. doi:10.3389/fbioe.2021.659431
  • Carqueijeiro I, Koudounas K, Dugé de Bernonville T, et al. Alternative splicing creates a pseudo-strictosidine β-d-glucosidase modulating alkaloid synthesis in Catharanthus roseus. Plant Physiol. 2021;185(3):836-856. doi:10.1093/plphys/kiaa075
  • Perrin J, Kulagina N, Unlubayir M, et al. Exploiting Spermidine N-Hydroxycinnamoyltransferase Diversity and Substrate Promiscuity to Produce Various Trihydroxycinnamoyl Spermidines and Analogues in Engineered Yeast. ACS Synth Biol. 2021;10(2):286-296. doi:10.1021/acssynbio.0c00391
  • Stander EA, Papon N, Courdavault V. Puzzling Out the Colchicine Biosynthetic Pathway. ChemMedChem. 2021;16(4):621-623. doi:10.1002/cmdc.202000633
  • Kulagina N, Papon N, Courdavault V. Microbial Cell Factories for Tetrahydroisoquinoline Alkaloid Production. Chembiochem. 2021;22(4):639-641. doi:10.1002/cbic.202000579
  • Guirimand G, Kulagina N, Papon N, Hasunuma T, Courdavault V. Innovative Tools and Strategies for Optimizing Yeast Cell Factories. Trends Biotechnol. 2021;39(5):488-504. doi:10.1016/j.tibtech.2020.08.010
  • Courdavault V, Cassereau J, Papon N. Engineered Microbes for Producing Anticholinergics. Chembiochem. 2021;22(8):1368-1370. doi:10.1002/cbic.202000757

Collaborative papers in 2021

  • Djeghdir I, Chefdor F, Bertheau L, et al. Evaluation of type-B RR dimerization in poplar: A mechanism to preserve signaling specificity?. Plant Sci. 2021;313:111068. doi:10.1016/j.plantsci.2021.111068
  • Roumani M, Besseau S, Gagneul D, Robin C, Larbat R. Phenolamides in plants: an update on their function, regulation, and origin of their biosynthetic enzymes. J Exp Bot. 2021;72(7):2334-2355. doi:10.1093/jxb/eraa582
  • Cassereau J, Courdavault V, Nägerl UV. Turning up the Green Light. Trends Cell Biol. 2021;31(3):143-145. doi:10.1016/j.tcb.2020.12.007