Grape polyphenols

Grapevines and their byproducts produce a broad range of specialized metabolites, including flavonoid- and stilbenoid-type compounds, which exhibit diverse biological activities highly sought by biomass-based industries. Among the large molecular diversity present in grape, only few lead molecules are exploited. This is the case for resveratrol; currently exploited as food supplements and cosmetics ingredient for its anti-aging properties and for oligomeric pro-anthocyanidins (OPCs) that are used for several health purposes including the prevention of cardiac and Alzheimer diseases. Beyond these two well-known lead molecules, grapevine is a natural source for a myriad of other biomass-derived molecules that remains underexplored. The objective of our group is to develop explore the metabolic diversity of grape in berries but also in by-products of viticulture for the development of novel grape biomass-derived chemicals with outputs in pharmacy, cosmetics and biocontrol. We are particularly interested in the development of metabolomics tools combined to chemometrics to unravel metabolic regulations in the vineyards.

Figure from Billet et al. (2020;DOI: 10.1007/978-3-030-51034-3_9) : Polyphenol biosynthetic pathway in grape canes.
Biosynthetic enzymes are presented in red. Stilbenoids in bold are present in V. Vinifera L. while others refer to non-vinifera grape Varieties.

• To explore the metabolic diversity of grapevines
• To develop UPLC-DAD-MS/MS metabolomic tools combined to chemometrics
• To unravel grape metabolic variations under genetic and environmental changes
• To valorize grape byproducts for applications in biocontrol, cosmetics and nutraceutics
• KEYWORDS : polyphenols; metabolomics; mass spectrometry; ultra-performance liquid chromatography; chemometrics; natural ingredients; biological activities; biocontrol, cosmetics; nutraceutics
   
  
  
  Field-based metabolomic revealed discriminations according to the genotypes according to pedigree information (Science&Wine)
  
  
  
  Figure from Billet et al. (2018; doi.org/10.1002/ps.5237 ): Grape wood biomass is extracted for biocontrol treatments in a virtuous recycling loop