Website Research Unit BBV
Characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications
Our mission
These projects are based on molecular biology, cell biology, biochemistry and genomics and metabolomics approaches.
Watch our motion design about our research projects : Exploiting yeasts to fight anticancer drug shortage
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ADN, l'ère de l'écriture Dans son article intitulé ADN, l'ère de l'écriture, M. Clastre explore le passage de la "lecture" à "l'écriture" de l'ADN dans le domaine des sciences de la vie. Inspiré par les œuvres de Borges, il aborde comment la biologie moderne se tourne désormais vers l’encodage de données dans l'ADN pour préserver le patrimoine de l'humanité. Une réflexion sur l'évolution de la biologie et les nouvelles possibilités offertes par la biologie synthétique. | |
Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans This article explores how monoterpene indole alkaloids (MIAs), plant compounds with medicinal properties, could be harnessed for drug production. The researchers sequenced the genome of Tabernaemontana elegans to uncover genes linked to the synthesis of pachysiphine, an MIA with anticancer and anti-Alzheimer potential. By identifying key enzymes and engineering MIA production in yeast, this study opens the door to new biotechnological approaches for producing pachysiphine-based pharmaceuticals. | |
Design and development of multibiocomponent hybrid alginate hydrogels and lipid nanodispersion as new materials for medical and cosmetic applications Bialik-Wąs K, Kulawik-Pióro A, Sienkiewicz A, Łętocha A, Osińska J, Malarz K, Mrozek-Wilczkiewicz A, Barczewski M, Lanoue A, Giglioli-Guivarc'h N, Miastkowska M. Int J Biol Macromol. 2024 Oct;278(Pt 1):134405. doi: 10.1016/j.ijbiomac.2024.134405. | |
Plant drugs: Transcending the mescaline biosynthesis Courdavault V, Papon N. Curr Biol. 2024 34(16):R791-R793. doi: 10.1016/j.cub.2024.06.061. | |
Unlocking plant bioactive pathways: omics data harnessing and machine learning assisting This review highlights the recent breakthroughs in disrupting plant-specialized biosynthetic pathways through the utilization of omics data harnessing and machine learning techniques | |
Metabolic engineering of the paclitaxel anticancer drug Oudin A, Papon N, Courdavault V. Cell Res. 2024 Jul;34(7):475-476. doi: 10.1038/s41422-024-00950-3. | |
The Madagascar palm genome provides new insights on the evolution of Apocynaceae specialized metabolism. Cuello C, Jansen HJ, Abdallah C, Zamar Mbadinga DL, Birer Williams C, Durand M, Oudin A, Papon N, Giglioli-Guivarc'h N, Dirks RP, Jensen MK, O'Connor SE, Besseau S, Courdavault V. Heliyon. 2024 Mar 14;10(6):e28078. doi: 10.1016/j.heliyon.2024.e28078. |
Read more articles from 2024, 2022/2023 and 2020/2021