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Microscopy view of Alstonia tissue

HPLC analysis lab

Our publications 2024

Characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications

Financial Partners of BIOPROPHARM research project

Our mission

The Plant Biomolecules and Biotechnology (BBV) laboratory is developing several research projects on the characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications.
These projects are based on molecular biology, cell biology, biochemistry and genomics and metabolomics approaches.

Watch our motion design about our research projects : Exploiting yeasts to fight anticancer drug shortage

Visit the website of our ANR project MIACYC !

Visit the website of the Horizon Europe project COMBO

Our TEAM

Permanent Professors and associate Professors

Post-doc and PhD Students

Engineers and technical staff

Read our last articles

	ADN, l'ère de l'écriture Dans son article intitulé ADN, l'ère de l'écriture, M. Clastre explore le passage de la "lecture" à "l'écriture" de l'ADN dans le domaine des sciences de la vie. Inspiré par les œuvres de Borges, il aborde comment la biologie moderne se tourne désormais vers l’encodage de données dans l'ADN pour préserver le patrimoine de l'humanité. Une réflexion sur l'évolution de la biologie et les nouvelles possibilités offertes par la biologie synthétique.
	Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans This article explores how monoterpene indole alkaloids (MIAs), plant compounds with medicinal properties, could be harnessed for drug production. The researchers sequenced the genome of Tabernaemontana elegans to uncover genes linked to the synthesis of pachysiphine, an MIA with anticancer and anti-Alzheimer potential. By identifying key enzymes and engineering MIA production in yeast, this study opens the door to new biotechnological approaches for producing pachysiphine-based pharmaceuticals.
	Design and development of multibiocomponent hybrid alginate hydrogels and lipid nanodispersion as new materials for medical and cosmetic applications Bialik-Wąs K, Kulawik-Pióro A, Sienkiewicz A, Łętocha A, Osińska J, Malarz K, Mrozek-Wilczkiewicz A, Barczewski M, Lanoue A, Giglioli-Guivarc'h N, Miastkowska M. Int J Biol Macromol. 2024 Oct;278(Pt 1):134405. doi: 10.1016/j.ijbiomac.2024.134405.
	Plant drugs: Transcending the mescaline biosynthesis Courdavault V, Papon N. Curr Biol. 2024 34(16):R791-R793. doi: 10.1016/j.cub.2024.06.061.
	Unlocking plant bioactive pathways: omics data harnessing and machine learning assisting This review highlights the recent breakthroughs in disrupting plant-specialized biosynthetic pathways through the utilization of omics data harnessing and machine learning techniques
	Metabolic engineering of the paclitaxel anticancer drug Oudin A, Papon N, Courdavault V. Cell Res. 2024 Jul;34(7):475-476. doi: 10.1038/s41422-024-00950-3.
	The Madagascar palm genome provides new insights on the evolution of Apocynaceae specialized metabolism. Cuello C, Jansen HJ, Abdallah C, Zamar Mbadinga DL, Birer Williams C, Durand M, Oudin A, Papon N, Giglioli-Guivarc'h N, Dirks RP, Jensen MK, O'Connor SE, Besseau S, Courdavault V. Heliyon. 2024 Mar 14;10(6):e28078. doi: 10.1016/j.heliyon.2024.e28078.