Website Research Unit BBV
Characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications
Financial Partners of BIOPROPHARM research project
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These projects are based on molecular biology, cell biology, biochemistry and genomics and metabolomics approaches.
Visit the websites dedicated to our ANR and Horizon Europe projects
Watch our motion design about our bioproduction research projects : Exploiting yeasts to fight anticancer drug shortage
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 | Geissoschizine Cyclase: A Discovery Revolutionizing the Understanding and Synthesis of Pharmacologically Important Monoterpenoid Indole Alkaloids As part of the MIACYC project, a major breakthrough has been made in understanding the enzymatic mechanisms responsible for the synthesis of monoterpenoid indole alkaloids (MIAs), valuable compounds with various pharmacological applications. Through combined transcriptomic analyses of the epidermis and leaves of Alstonia scholaris, enhanced by the overexpression of the transcriptional regulator MYC2, our teams identified a key enzyme: geissoschizine cyclase. |
 | A GAME changer in steroidal metabolite biosynthesis Lezin E, Papon N, Courdavault V. A t Commun. 2024 Dec 3:101201. doi: 10.1016/j.xplc.2024.101201. |
 | Unlocking specialized metabolism in medicinal plant biotechnology through plant-microbiome interactions In this article we propose expanding the concept of culturomics to encompass the co-culture of synthetic microbial communities with medicinal plant in vitro culture. This approach will take advantage to mimic the complex interactions to finally trigger the secondary metabolite production. |
 | Metabolomics applications in natural cosmetics: addressing the new challenges of bio-sourced ingredients The increasing demand of natural ingredients in cosmetics raises new challenges for the characterization of highly complex natural extracts. This review presents the current development of metabolomics applied to natural cosmetic ingredients. |
 | ADN, l'ère de l'écriture Dans son article intitulé ADN, l'ère de l'écriture, M. Clastre explore le passage de la "lecture" à "l'écriture" de l'ADN dans le domaine des sciences de la vie. Inspiré par les œuvres de Borges, il aborde comment la biologie moderne se tourne désormais vers l’encodage de données dans l'ADN pour préserver le patrimoine de l'humanité. Une réflexion sur l'évolution de la biologie et les nouvelles possibilités offertes par la biologie synthétique. |
 | Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans This article explores how monoterpene indole alkaloids (MIAs), plant compounds with medicinal properties, could be harnessed for drug production. The researchers sequenced the genome of Tabernaemontana elegans to uncover genes linked to the synthesis of pachysiphine, an MIA with anticancer and anti-Alzheimer potential. By identifying key enzymes and engineering MIA production in yeast, this study opens the door to new biotechnological approaches for producing pachysiphine-based pharmaceuticals. |
Read more articles from 2025, 2024, 2022/2023 and 2020/2021
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