Publications 2024/2025
2025
- Evolution of CYP71D drives the diversification of monoterpene indole alkaloid biosynthesis in Gentianales17 mai 2025 - 31 mars 2027Besseau S, Durand M, Zamar DL, Lezin E, Méteignier LV, Birer Williams C, Dutilleul C, Perrot T, Lanoue A, Oudin A, Papon N, Massiot G, Sun C, St-Pierre B, Courdavault V. Evolution of CYP71D drives the diversification of monoterpene indole alkaloid biosynthesis in Gentianales. Plant Commun. 2025 May 19:101381. doi: 10.1016/j.xplc.2025.101381.
- Geissoschizine Cyclase: A Discovery Revolutionizing the Understanding and Synthesis of Pharmacologically Important Monoterpenoid Indole Alkaloids10 décembre 2024As part of the MIACYC project, a major breakthrough has been made in understanding the enzymatic mechanisms responsible for the synthesis of monoterpenoid indole alkaloids (MIAs), valuable compounds with various pharmacological applications. Through combined transcriptomic analyses of the epidermis and leaves of Alstonia scholaris, enhanced by the overexpression of the transcriptional regulator MYC2, our teams identified a key enzyme: geissoschizine cyclase.
2024
- Metabolic engineering of the paclitaxel anticancer drug10 décembre 2024 - 1 février 2026A.Oudin, N. Papon, V. Courdavault. Cell research, 34, 475-476 (2024)
- A GAME changer in steroidal metabolite biosynthesis3 décembre 2024 - 3 décembre 2028Lezin E, Papon N, Courdavault V. A t Commun. 2024 Dec 3:101201. doi: 10.1016/j.xplc.2024.101201.
- Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans20 octobre 2024 - 1 février 2027This article explores how monoterpene indole alkaloids (MIAs), plant compounds with medicinal properties, could be harnessed for drug production. The researchers sequenced the genome of Tabernaemontana elegans to uncover genes linked to the synthesis of pachysiphine, an MIA with anticancer and anti-Alzheimer potential. By identifying key enzymes and engineering MIA production in yeast, this study opens the door to new biotechnological approaches for producing pachysiphine-based pharmaceuticals.
- Unlocking plant bioactive pathways: omics data harnessing and machine learning assisting24 mai 2024 - 1 février 2026
- The Madagascar palm genome provides new insights on the evolution of Apocynaceae specialized metabolism.30 mars 2024 - 1 février 2026Cuello C, Jansen HJ, Abdallah C, Zamar Mbadinga DL, Birer Williams C, Durand M, Oudin A, Papon N, Giglioli-Guivarc'h N, Dirks RP, Jensen MK, O'Connor SE, Besseau S, Courdavault V. Heliyon. 2024 Mar 14;10(6):e28078. doi: 10.1016/j.heliyon.2024.e28078.
- Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast.6 mars 2024 - 1 février 2026Perrot T, Marc J, Lezin E, Papon N, Besseau S, Courdavault V. Curr Opin Biotechnol. 2024 Jun;87:103098. doi: 10.1016/j.copbio.2024.103098.
- SPOTLIGHT: Alpha carbonic anhydrases join the club of alkaloid biosynthetic enzymes6 mars 2024 - 1 février 2026Zamar DL, Papon N, Courdavault V. J Plant Physiol. 2024 Feb;293:154169. doi: 10.1016/j.jplph.2023.154 169
- A chromosome-scale genome assembly of Rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway28 décembre 2023 - 1 février 2026Lezin E, Carqueijeiro I, Cuello C, Durand M, Jansen HJ, Vergès V, Birer Williams C, Oudin A, Dugé de Bernonville T, Petrignet J, Celton N, St-Pierre B, Papon N, Sun C, Dirks RP, O'Connor SE, Jensen MK, Besseau S, Courdavault V. Plant Commun. 2024 Apr 8;5(4):100784. doi: 10.1016/j.xplc.2023.100784.
