Publications 2024/2025

As part of the MIACYC project, a major breakthrough has been made in understanding the enzymatic mechanisms responsible for the synthesis of monoterpenoid indole alkaloids (MIAs), valuable compounds with various pharmacological applications. Through combined transcriptomic analyses of the epidermis and leaves of Alstonia scholaris, enhanced by the overexpression of the transcriptional regulator MYC2, our teams identified a key enzyme: geissoschizine cyclase.

Lezin E, Papon N, Courdavault V. A t Commun. 2024 Dec 3:101201. doi: 10.1016/j.xplc.2024.101201.

In this article we propose expanding the concept of culturomics to encompass the co-culture of synthetic microbial communities with medicinal plant in vitro culture. This approach will take advantage to mimic the complex interactions to finally trigger the secondary metabolite production.

The increasing demand of natural ingredients in cosmetics raises new challenges for the characterization of highly complex natural extracts. This review presents the current development of metabolomics applied to natural cosmetic ingredients.

This article explores how monoterpene indole alkaloids (MIAs), plant compounds with medicinal properties, could be harnessed for drug production. The researchers sequenced the genome of Tabernaemontana elegans to uncover genes linked to the synthesis of pachysiphine, an MIA with anticancer and anti-Alzheimer potential. By identifying key enzymes and engineering MIA production in yeast, this study opens the door to new biotechnological approaches for producing pachysiphine-based pharmaceuticals.

In this literature review, we present the advantage of metabolomic approaches to evaluate the cosmetic potential of fungus-resistant varieties cultivated in Central and Eastern Europe.

Bialik-Wąs K, Kulawik-Pióro A, Sienkiewicz A, Łętocha A, Osińska J, Malarz K, Mrozek-Wilczkiewicz A, Barczewski M, Lanoue A, Giglioli-Guivarc'h N, Miastkowska M. Int J Biol Macromol. 2024 Oct;278(Pt 1):134405. doi: 10.1016/j.ijbiomac.2024.134405.

Mina S, Hérivaux A, Yaakoub H, Courdavault V, Wéry M, Papon N. Curr Genet. 2024 Sep 14;70(1):17. doi: 10.1007/s00294-024-01301-w.

Oudin A, Papon N, Courdavault V. Cell Res. 2024 Jul;34(7):475-476. doi: 10.1038/s41422-024-00950-3.

Courdavault V, Papon N. Curr Biol. 2024 34(16):R791-R793. doi: 10.1016/j.cub.2024.06.061.

In this article, we tested the foliar application of polyols on grapevines to improve the quality-related traits through the stimulation of the secondary metabolism. An array of metabolomics, enzyme activities and transcriptional analysis approaches were used to investigate this hypothesis.

Munsch T, Malinowska MA, Unlubayir M, Ferrier M, Abdallah C, Gémin MP, Billet K, Lanoue A. Food Chem X. 2024 Apr 7;22:101362. doi: 10.1016/j.fochx.2024.101362.

Yun L, Zhang C, Liang T, Tian Y, Ma G, Courdavault V, Sun S, Ma B, Li Z, Li R, Cao F, Shen X, Wei J, Li Y, Guo B, Sun C. Plant Commun. 2024 Aug 12;5(8):100932. doi: 10.1016/j.xplc.2024.100932.

Courdavault V, Papon N. Nat Chem Biol. 2024 Apr;20(4):401-403. doi: 10.1038/s41589-024-01585-6.

Pedenla Bomzan D, Sharma A, Lemos Cruz P, Carqueijeiro I, Bellenger L, Rai A, Thippesh AK, Chinnegowda VS, Parihar D, Ducos E, Courdavault V, Nagegowda DA. Physiol. 2024 Jun 28;195(3):2213-2233. doi: 10.1093/plphys/kiae142.

Bradley SA, Hansson FG, Lehka BJ, Rago D, Pinho P, Peng H, Adhikari KB, Haidar AK, Hansen LG, Volkova D, Holtz M, Muyo Abad S, Ma X, Koudounas K, Besseau S, Gautron N, Mélin C, Marc J, Birer Williams C, Courdavault V, Jensen ED, Keasling JD, Zhang J, Jensen MK. ACS Synth Biol. 2024 May 17;13(5):1498-1512. doi: 10.1021/acssynbio.4c00039.

Courdavault V, Papon N. Nat Rev Genet. 2024 May;25(5):307. doi: 10.1038/s41576-024-00705-1.

Cuello C, Jansen HJ, Abdallah C, Zamar Mbadinga DL, Birer Williams C, Durand M, Oudin A, Papon N, Giglioli-Guivarc'h N, Dirks RP, Jensen MK, O'Connor SE, Besseau S, Courdavault V. Heliyon. 2024 Mar 14;10(6):e28078. doi: 10.1016/j.heliyon.2024.e28078.

Perrot T, Marc J, Lezin E, Papon N, Besseau S, Courdavault V. Curr Opin Biotechnol. 2024 Jun;87:103098. doi: 10.1016/j.copbio.2024.103098.

Zamar DL, Papon N, Courdavault V. J Plant Physiol. 2024 Feb;293:154169. doi: 10.1016/j.jplph.2023.154 169

Lezin E, Carqueijeiro I, Cuello C, Durand M, Jansen HJ, Vergès V, Birer Williams C, Oudin A, Dugé de Bernonville T, Petrignet J, Celton N, St-Pierre B, Papon N, Sun C, Dirks RP, O'Connor SE, Jensen MK, Besseau S, Courdavault V. Plant Commun. 2024 Apr 8;5(4):100784. doi: 10.1016/j.xplc.2023.100784.