Unlocking specialized metabolism in medicinal plant biotechnology through plant-microbiome interactions
- Pharmacie,
- Santé-Sciences-Technologie,
le 1 décembre 2024
Site Grandmont
In this article we propose expanding the concept of culturomics to encompass the co-culture of synthetic microbial communities with medicinal plant in vitro culture. This approach will take advantage to mimic the complex interactions to finally trigger the secondary metabolite production.
https://doi.org/10.1016/j.pbi.2024.102620.
Abstract
Medicinal plants produce specialized metabolites (SM) that are used as drugs. However, due to low yields of field cultivation and the increasing market demand, this production method often failed to meet supply needs. Biotechnological alternatives, such as in vitro plant cultures, offer promising solutions. Nonetheless, SM production in these systems remains too low for industrial exploitation, necessitating an elicitation step to induce the plant defense metabolism. Traditional elicitation methods mimic environmental conditions that trigger plant-specialized metabolism, often with an artificial signal that mimics microbial interaction. Recent insights into the essential role of the plant microbiota, provides new opportunities for elicitation strategies by microbial coculture in a controlled environment. The successful co-culture of in vitro medicinal plants with synthetic microbial communities could enable sustainable production of pharmaceutically important SM.
Keywords: In vitro cultures; Medicinal plants; Specialized metabolites; Elicitation; Microbiome; Culturomics; Synthetic Communities
