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Characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications
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 | The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis The Vinca minor genome finally assembled! Our new publication in G3!The Vinca minor plant synthesizes monoterpene indole alkaloids (MIAs), which are a class of specialized metabolites displaying a wide range of bioactive- and pharmacologically important properties. V. minor mainly accumulates vincamine, which is commercially used as a nootropic. Using a combination of Oxford Nanopore Technologies long read- and Illumina short-read sequencing, a 679,098 Mb V. minor genome was assembled into 296 scaffolds with an N50 scaffold length of 6 Mb, and encoding 29,624 genes. |
 | Marine drug metabolism consortium - 1st meeting We organised with Le Studium, a first meeting with our partners to discuss about our project dedicated to marine drug products to provide innovative solutions for supplying these high values molecules. |
 | A microbial supply chain for production of the anti-cancer drug vinblastine published in NATURE! The authors engineered yeast to produce the cancer therapeutic vinblastine. A promising achievement for the synthetis of therapeutic natural products. This is the latest research of several teams including MIAMi project collaborators. Dr Vincent Courdavault , assistant professor in our lab and Emily A. Stander, former post-doctoral researcher are co-authors of this paper published in Nature. |
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The Plant Biomolecules and Biotechnology (BBV) laboratory is developing several research projects on the characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications.These projects are based on molecular biology, cell biology, biochemistry and genomics and metabolomics approaches.
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- The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis18 octobre 2022The Vinca minor genome finally assembled! Our new publication in G3!The Vinca minor plant synthesizes monoterpene indole alkaloids (MIAs), which are a class of specialized metabolites displaying a wide range of bioactive- and pharmacologically important properties. V. minor mainly accumulates vincamine, which is commercially used as a nootropic. Using a combination of Oxford Nanopore Technologies long read- and Illumina short-read sequencing, a 679,098 Mb V. minor genome was assembled into 296 scaffolds with an N50 scaffold length of 6 Mb, and encoding 29,624 genes.
- A microbial supply chain for production of the anti-cancer drug vinblastine published in NATURE!31 août 2022The authors engineered yeast to produce the cancer therapeutic vinblastine. A promising achievement for the synthetis of therapeutic natural products. This is the latest research of several teams including MIAMi project collaborators. Dr Vincent Courdavault , assistant professor in our lab and Emily A. Stander, former post-doctoral researcher are co-authors of this paper published in Nature.
- Impact of Deficit Irrigation on Grapevine cv. ‘Touriga Nacional’ during Three Seasons in Douro Region: An Agronomical and Metabolomics Approach9 mars 2022Impact of Deficit Irrigation on Grapevine cv. ‘Touriga Nacional’ during Three Seasons in Douro Region: An Agronomical and Metabolomics Approach , a collaborative article with Pr Geros from the University do Minho, (Portugal)
- Social amoebae as a new chassis for drug production21 février 2022 - 21 février 2024Social amoebae as a new chassis for drug production : our new spotlight published in Trends in Biotechnology
- Chromosome-scale genomes throw light on plant drug biosynthesis14 février 2022 - 30 septembre 2024Recent chromosome-scale genomes from prominent medicinal plants have provided unprecedent insight into the architecture and evolution of some prominent metabolic pathways. A story related in our new paper published in Trends in Pharmacological Sciences!
- Marine drugs: Biology, pipelines, current and future prospects for production13 décembre 2021 - 30 juin 2024Do you know that marine organisms represent a huge reservoir of new pharmaceuticals? If you are interested, read our new research review paper published in Biotechnology advances!
- Yeasts as Biopharmaceutical Production Platforms30 septembre 2021 - 30 juin 2024Curious about what kind of proteins or natural products are currently in yeast? Read our new opinion paper in Frontiers in Fungal Biology associating MYACIC project.
- Tonoplast and Peroxisome Targeting of γ-tocopherol N-methyltransferase Homologs Involved in the Synthesis of Monoterpene Indole AlkaloidsA research article published in Plant and Cell Physiology in november 2021.
- Efficient Terpene Production by Marine Thraustochytrids: Shedding Light on the Thermodynamic Driving ForceAn article published in mBio in october 2021.
- Postharvest Treatment of Wood Biomass from a Large Collection of European Grape Varieties: Impact on the Selection of Polyphenol-Rich ByproductsA research article published in ACS sustainable Chemistry & Engineering in february 2021.
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