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Characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications

Breaking news

The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis

The Vinca minor genome finally assembled! Our new publication in G3!The Vinca minor plant synthesizes monoterpene indole alkaloids (MIAs), which are a class of specialized metabolites displaying a wide range of bioactive- and pharmacologically important properties. V. minor mainly accumulates vincamine, which is commercially used as a nootropic. Using a combination of Oxford Nanopore Technologies long read- and Illumina short-read sequencing, a 679,098 Mb V. minor genome was assembled into 296 scaffolds with an N50 scaffold length of 6 Mb, and encoding 29,624 genes.

Marine drug metabolism consortium - 1st meeting

We organised with Le Studium, a first meeting with our partners to discuss about our project dedicated to marine drug products to provide innovative solutions for supplying these high values molecules.

A microbial supply chain for production of the anti-cancer drug vinblastine published in NATURE!

The authors engineered yeast to produce the cancer therapeutic vinblastine. A promising achievement for the synthetis of therapeutic natural products. This is the latest research of several teams including MIAMi project collaborators. Dr Vincent Courdavault , assistant professor in our lab and Emily A. Stander, former post-doctoral researcher are co-authors of this paper published in Nature.



Our mission

The Plant Biomolecules and Biotechnology (BBV) laboratory is developing several research projects on the characterization of specialized plant metabolisms by developing biotechnological and metabolic engineering processes aimed at producing metabolites of interest for pharmaceutical, cosmetic or agronomic applications.
These projects are based on molecular biology, cell biology, biochemistry and genomics and metabolomics approaches.

Our TEAM

Permanent Professors and associate Professors
Post-doc and PhD Students
Engineers and technical staff

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Access to the lab

Biomolecule and Plant Biotechnology (BBV)

31, avenue Monge
37200 Tours
 
bbv@univ-tours.fr