2023

In this collobarative work, we show that biologically active phenolic compounds, including stilbenoids,accumulate in the woody canes during bud burst.

Published in Nature Chemical Biology, this collaborative work demonstrates a scalable de novo manufacturing platform for bioactive monoterpenoid indole alkaloids (MIAs, plant metabolites that possess various medicinal properties) in yeast and provides a foundation for further pathway refactoring toward microbial biosynthesis of both native and new-to-nature MIAs.

In this study we developed in vitro shoot cultures of grapevine cultivars from Poland as a source of polyphenols with cosmetics interest.

In this study we developed in vitro shoot cultures of grapevine cultivars from Poland as a source of polyphenols with cosmetics interest.

In this study, we hypothesized that the grapevine cultivar has a direct effect on the metabolome of grape berries, subsequently affecting their microbial fingerprint.

The aim of this study was to assess the terroir influence on the polyphenol composition ingrape canes using a spatial metabolomics approach.

Our new spotlight published in Trends in Plant Science, on a report by Li et al on single-cell multi-omics approach used to elucidate the architecture and regulation of anticancer alkaloid biosynthesis in medicinal plants.

In this highlight published in ChemBioChem, we discuss how tropane alkaloid biosynthesis evolved via the recruitment of two distinct and convergent pathways in Erythroxylaceae and Solanaceae.

In this study published in Phytochemistry, we explore how matrix assisted laser desorption ionization (MALDI) and desorption electrospray ionization (DESI) mass spectrometry imaging (MSI) can be used in the investigation of a proposed biosynthetic pathway by localizing reserpine and the theoretical intermediates of it

A spotlight in Trends in genetics about the convergent evolution for antibiotic biosynthesis in bacteria and animals.

A research performed in collaboration with Agricultural University of Athens on new pioneer practice to enrich polyphenols in grape by the application of biostimulants on grapevines

Read our collaborative article with Pr Queiroz from the University of Porto and Pr Geros from the University of Minho, (Portugal). Climate changes are speeding up the maturation of grapes, but warmer temperatures often uncouple technical and phenolic maturity. We tested the efficacy of crop forcing in delaying the maturation of cv. ‘Touriga Nacional’ vines of the Douro Region, and their impacts on plant performance, berry quality attributes and metabolome

Published in Nature Plants, this review focuses on translational, transcriptional, epigenetic and chromatin-based regulation and evolution of specialized metabolism genes, a new and forefront research filed. We extrapolate to medicinal plants that synthetize rare molecules and also discuss how this new knowledge could help in improving strategies to produce useful plant-derived pharmaceuticals.

We identified a second isoform of 16-hydroxytabersonine-O-methyltransferase enzyme that suggests an evolutionary relationship between alkaloid and flavonoid metabolisms in the Madagascar Periwinkle, a plant producing anti-cancer drugs - our new article in Protoplasma!