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We're hiring! Post-doctoral fellowship in plant and yeast metabolic engineering

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Date(s)

du 1 mars 2022 au 31 juillet 2023

from March 2022
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Site Grandmont

EA2106 - Plant Biomolecules and Biotechnology

We are looking for a full-time postdoctoral researcher that will be involved in an exciting research program funded by the Région Centre-Val de Loire and focusing on the metabolic engineering of highly valuable plant natural products with an emphasize on lignans.

Post-doctoral proposal

A 18 months fellowship opening in March 2022. The eligible fellow will be granted social security benefits and will be paid 27,000 - 28,000 € (net wage) / year.

The candidate will carry out transfer of the plant biosynthetic genes in yeast to create the cell factories able to produce these compounds on demand. The candidate will be in charge of optimizing the synthesis of the targeted compounds in yeasts by adjusting gene copy balance or overexpressing genes encoding cofactor regenerating enzymes. In addition, the candidate will also be involved in the identification of more efficient biosynthetic enzymes by characterizing already predicted gene orthologues from different species. The candidate will also participate in scaling up the yeast culture and the synthesis of the lignans of interest. The recruited researcher will also benefit from the expertise of several assistant professors and other post-docs from EA2106 with recognized skills/experience in the study of the NP biosynthesis/metabolic engineering.

Expected profile

  • PhD in plant or yeast molecular biology
  • Hands-on experience in molecular biology, yeast engineering and culture, knowledge on CRIPR/Cas9 procedure would be appreciated
  • Spirit team and will of taking initiatives
  • Proficient use of the English language for both oral and written communications

Host Laboratory

The BBV laboratory (EA2106) from the University of Tours studies plant specialized metabolisms by combining both metabolomics and transcriptomics approaches. Besides unraveling biosynthetic pathways, our goal is to provide alternative supply of plant natural products by creating microbiological cell factories. Our english-speaking lab offers all facilities (computing grids, LC-MS/MS, greenhouses, confocal microscope) to achieve an efficient research and benefits from funds from the European H2020 program, the French Agence Nationale de la Recherche (ANR) and from regional research programs. Please visit us at: (https://bbv.univ-tours.fr/alkaloid-biosynthesis) (https://twitter.com/BBVEA2106_Tours). For this project, you will work under the supervision of Dr. Vincent Courdavault (https://twitter.com/v_courdavault) and Dr. Sébastien Besseau.

Application

To apply, please send your detailed CV (including list of publications), a motivation letter, and appreciation letters from two referees at vincent.courdavault@univ-tours.fr and sebastien.besseau@univ-tours.fr.